New paper: Determination of Tissue Potassium and Sodium Concentrations in Dystrophic Skeletal Muscle Tissue Using Combined Potassium (39K) and Sodium (23Na) MRI at 7T
Congratulations to Dr. Lena Gast and co-authors on the recently published article “Determination of Tissue Potassium and Sodium Concentrations in Dystrophic Skeletal Muscle Tissue Using Combined Potassium (39K) and Sodium (23Na) MRI at 7T”!
This study used combined Na/K MRI at 7T to assess apparent tissue potassium concentration (aTPC) in fat-replaced muscles of patients with facioscapulohumeral muscular dystrophy (FSHD). Results showed that aTPC was significantly reduced in fat-replaced muscles, approaching zero in fully replaced areas, while corrected aTPC (aTPCfc) remained similar to healthy controls in muscles with low fat content but decreased in those with higher fat fraction. These findings suggest that aTPCfc could serve as an additional quantitative biomarker for muscle degeneration beyond fat replacement.
The full article can be found here: